Jaan-Olle Andressoo Selected Research

Glial Cell Line-Derived Neurotrophic Factor (GDNF)

8/2022	Elevated endogenous GDNF induces altered dopamine signalling in mice and correlates with clinical severity in schizophrenia.
1/2021	Increased Endogenous GDNF in Mice Protects Against Age-Related Decline in Neuronal Cholinergic Markers.
6/2020	Chronic 2-Fold Elevation of Endogenous GDNF Levels Is Safe and Enhances Motor and Dopaminergic Function in Aged Mice.
1/2019	Gfra1 Underexpression Causes Hirschsprung's Disease and Associated Enterocolitis in Mice.
1/2019	Development of the urogenital system is regulated via the 3'UTR of GDNF.
1/2018	Two-fold elevation of endogenous GDNF levels in mice improves motor coordination without causing side-effects.
1/2018	Constitutive Ret signaling leads to long-lasting expression of amphetamine-induced place conditioning via elevation of mesolimbic dopamine.
1/2017	Dampened Amphetamine-Stimulated Behavior and Altered Dopamine Transporter Function in the Absence of Brain GDNF.
12/2015	GDNF Overexpression from the Native Locus Reveals its Role in the Nigrostriatal Dopaminergic System Function.

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Jaan-Olle Andressoo Research Topics

Disease

6	Parkinson Disease (Parkinson's Disease) 01/2021 - 07/2007
3	Neoplasms (Cancer) 06/2020 - 08/2006
2	Schizophrenia (Dementia Praecox) 08/2022 - 01/2018
2	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2021 - 01/2017
2	Mental Disorders (Mental Disorder) 01/2018 - 01/2017
1	Psychotic Disorders (Schizoaffective Disorder) 08/2022
1	Cognitive Dysfunction 01/2021
1	Dementia (Dementias) 01/2021
1	Alzheimer Disease (Alzheimer's Disease) 01/2021
1	Lewy Body Disease (Lewy Body Dementia) 01/2021
1	Cakut 01/2019
1	Enterocolitis 01/2019
1	Hirschsprung Disease (Hirschsprung's Disease) 01/2019
1	Infertility (Sterility) 01/2019
1	Multiple Endocrine Neoplasia Type 2b (MEN 3) 01/2018
1	Attention Deficit Disorder with Hyperactivity (Attention Deficit Hyperactivity Disorder) 01/2018
1	Stroke (Strokes) 01/2014
1	Neuroinflammatory Diseases 01/2014
1	Infarction (Infarctions) 01/2014
1	Ischemia 01/2014
1	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 01/2014
1	Status Epilepticus (Complex Partial Status Epilepticus) 11/2008
1	Premature Aging 12/2006
1	Hypoglycemia (Reactive Hypoglycemia) 12/2006
1	Hypersensitivity (Allergy) 12/2006
1	Cerebellar Ataxia (Dysmetria) 12/2006
1	Dwarfism 12/2006
1	Progeria (Hutchinson Gilford Syndrome) 08/2006
1	Xeroderma Pigmentosum (Kaposi's Disease) 08/2006
1	Trichothiodystrophy Syndromes 08/2006
1	Cockayne Syndrome (Syndrome, Cockayne) 08/2006
1	Weight Loss (Weight Reduction) 09/2004

Drug/Important Bio-Agent (IBA)

9	Glial Cell Line-Derived Neurotrophic Factor (GDNF)IBA 08/2022 - 12/2015
6	Dopamine (Intropin)FDA LinkGeneric 08/2022 - 12/2015
3	NucleotidesIBA 12/2006 - 08/2006
2	Dopamine Plasma Membrane Transport Proteins (Dopamine Transporter)IBA 01/2018 - 01/2017
1	Cholinergic Agents (Cholinergics)IBA 01/2021
1	Nerve Growth Factors (Neurotrophins)IBA 01/2020
1	MucinsIBA 01/2019
1	Glial Cell Line-Derived Neurotrophic Factors (GDNF Family Ligands)IBA 01/2019
1	3' Untranslated Regions (3' UTR)IBA 01/2019
1	6-chloro-2-(1-piperazinyl)pyrazine (CPP)IBA 01/2018
1	Amphetamine (Amfetamine)FDA LinkGeneric 01/2018
1	Proteasome InhibitorsIBA 12/2015
1	lactacystinIBA 12/2015
1	Chemotactic FactorsIBA 01/2014
1	Dietary ProteinsIBA 01/2014
1	LigandsIBA 01/2014
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2014
1	Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)IBA 01/2014
1	Brain-Derived Neurotrophic Factor (BDNF)IBA 01/2014
1	Messenger RNA (mRNA)IBA 11/2008
1	Oxidopamine (6 Hydroxydopamine)IBA 07/2007
1	Insulin-Like PeptidesIBA 12/2006
1	Blood Glucose (Blood Sugar)IBA 12/2006
1	Growth Hormone (Somatotropin)IBA 12/2006
1	DNA (Deoxyribonucleic Acid)IBA 12/2006
1	Diethylhexyl Phthalate (DEHP)IBA 09/2004

Therapy/Procedure

1	Diet Therapy (Therapy, Diet) 01/2014
1	Vascular Surgical Procedures 01/2014
1	Protein-Restricted Diet (Diet, Protein Restricted) 01/2014